The US and Israel have attacked Iran – President Donald Trump confirms “major combat operations” are under way, and calls for regime change

The office of Iran’s supreme leader, and the presidential office in Tehran, were reportedly targeted, as well as military sites across the country. At least 53 people were killed at a girls’ school, Iranian state media reports

Iran has launched retaliatory strikes on Israel, the Israeli military says. Damage – thought to be caused by Iranian attacks – has also been seen across the region, including in Qatar, the UAE and Kuwait

In Bahrain, where the US has a major naval base, the moment of an apparent Iranian missile attack was filmed from a car

Trump has urged Iranians to “take over” the government, saying: “This will be probably your only chance for generations”

There is a mixed response among ordinary Iranians, our reporter says: panic in the streets, but also – for some – a sense of relief

Washington has been ramping up the pressure on Tehran to agree to a new deal on its nuclear programme. Trump said on Friday he was “not happy” with Iran’s negotiating position during nuclear talks – our Middle East correspondent explains how we got here