Israeli soldiers work at the scene of damage after Iranian missile barrages struck Dimona, March 21, 2026 [Ilan Assayag/Reuters]
By Al Jazeera Staff, AFP and AP
The Israeli Ministry of Health says at least 180 people have been wounded in Iranian missile attacks on the southern city of Dimona – home to the country’s main nuclear facility – and nearby Arad, in one of the most dramatic escalations since the US-Israel war on Iran began.
Iranian state television framed Saturday’s strikes as a “response” to an attack on Iran’s Natanz nuclear enrichment complex earlier in the day, marking a stark new phase of tit-for-tat targeting in the conflict, now in its fourth week.
At least 116 people were wounded in Arad, including seven seriously, according to Israel’s Health Ministry, with extensive damage reported in the city centre.
Another 64 were wounded in Dimona, with one in serious condition, the ministry said, with multiple shrapnel wounds, after several residential buildings were destroyed.
Reports said the wounded included a 10-year-old boy.
Israeli Prime Minister Benjamin Netanyahu called it a “difficult” evening for Israel, and promised to continue attacking Iran, where US-Israeli attacks since February 28 have killed more than 1,500 people, including at least 200 children, according to Iranian state media.
An Israeli military spokesman said air defence systems were activated during the attacks, but failed to intercept some of the missiles, even though they were not “special or unfamiliar”.
“In both Dimona and Arad, interceptors were launched that failed to hit the threats, resulting in two direct hits by ballistic missiles with warheads weighing hundreds of kilograms,” firefighters said.
Al Jazeera’s Nour Odeh, reporting from Ramallah in the occupied West Bank, said three separate impact sites had been identified across Dimona, with one three-storey building collapsing and several fires breaking out.
A video shot by a witness and verified by Al Jazeera, which is banned from operating inside Israel, showed a missile striking the city, followed by a large explosion.
The International Atomic Energy Agency (IAEA) said it had received no indication of damage to the Shimon Peres Negev Nuclear Research Center in Dimona, and that no abnormal radiation levels had been detected in the area.
The nuclear watchdog said it was closely monitoring the situation, with Director General Rafael Grossi urging that “maximum military restraint should be observed, in particular in the vicinity of nuclear facilities”.
Dimona has been at the heart of Israel’s nuclear programme since its research centre, built in secret with French assistance, opened there in 1958.
Israel’s Health Ministry said at least 4,564 people have been taken to hospitals since the start of the war. Of them, 124 are currently hospitalised, including one in critical condition and 13 in serious condition, it added.
Iran on Saturday said the US and Israel had targeted its Natanz enrichment complex, though it reported no radioactive leakage.
An unnamed Israeli official, quoted by The Associated Press news agency, denied that Israel was responsible for the Natanz strike, but the Israeli army has not released a full statement on the matter.
Also on Saturday, the Israeli military announced it had struck a research and development facility at Tehran’s Malek Ashtar University, which it said had been used to develop components for nuclear weapons and ballistic missiles.
The military said it “will not allow the Iranian regime to acquire nuclear weapons”.
Israel is believed to have developed nuclear weapons by the late 1960s. Its policy of deliberate ambiguity, neither confirming nor denying their existence, was part of a deal quietly struck with Washington, which judged that an open declaration would risk triggering a regional arms race.
Abas Aslani, a senior fellow at the Centre for Middle East Strategic Studies in Tehran, told Al Jazeera that Iran has been pursuing an eye-for-an-eye approach designed to re-establish deterrence.
“Tehran wants to reduce the gap between words and actions,” he said, adding that Iran’s goal was to make its threats credible enough to underpin a new long-term security arrangement, not to simply force a ceasefire, but to establish deterrence.