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The US and Israel have attacked Iran – President Donald Trump confirms\u00a0“major combat operations”<\/a>\u00a0are under way, and calls for regime change<\/p>\n<\/li>\n The office of Iran’s supreme leader, and the presidential office in Tehran, were reportedly targeted,\u00a0as well as military sites across the country<\/a>. At least 53 people were killed at a girls’ school,\u00a0Iranian state media reports<\/a><\/p>\n<\/li>\n Iran has launched retaliatory strikes on Israel,\u00a0the Israeli military says<\/a>. Damage – thought to be caused by Iranian attacks – has also been seen across the region, including in\u00a0Qatar<\/a>, the\u00a0UAE<\/a>\u00a0and\u00a0Kuwait<\/a><\/p>\n<\/li>\n In Bahrain, where the US has a major naval base,\u00a0the moment of an apparent Iranian missile attack was filmed from a car<\/a><\/p>\n<\/li>\n Trump has urged Iranians to\u00a0“take over” the government<\/a>, saying: “This will be probably your only chance for generations”<\/p>\n<\/li>\n There is a mixed response among ordinary Iranians, our reporter says:\u00a0panic in the streets, but also – for some – a sense of relief<\/a><\/p>\n<\/li>\n Washington has been ramping up the pressure on Tehran to agree to a new deal on its nuclear programme.\u00a0Trump said on Friday<\/a>\u00a0he was “not happy” with Iran’s negotiating position during nuclear talks –\u00a0our Middle East correspondent explains how we got here<\/a><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n